The study aimed to assess the efficacy of three different drugs against nematodiasis in goat. Twenty goats were divided into 4 groups of 5 animals each. Group ‘D’ served as the control, whereas groups A, B, and C were treated with ivermectin, fenbendazole and albendazole respectively. The therapeutic efficacy was evaluated through determination of eggs per gram (EPG) count, haematological findings and body weight gain or loss. Faecal and blood samples were collected before treatment on day 0, and on post-treatment days 7, 14, 21 and 28 of study. Pre and post-treatment EPG values were recorded and efficacies compared. The results showed that the efficacy about albendazole 87%, ivermectin 85% and fenbendazole 92%. The haematological parameters, TLC, Hb and PCV values were lower on day 0 but turned to increase (p<0.01) on day 28 of the study. On the other hand, ESR and TEC were higher before treatment (day 0) but decreased significantly (p<0.01) on day 28. The body weight of the treated animals were faintly increased which were significant (p<0.01). It was concluded that the farm management practices along with results of the present study revealed the efficacy of multiple anthelmintics against nematodiasis in goats. 1405327071.php