In the present study 40 albino wistar rats were divided uniformly into four equal groups viz. I, II, III & IV. Group I served as control and received groundnut oil. Group II and group III rats were orally administered with vitamin E @ 100 mg/kg b.wt. and dimethoate @ 40 mg/kg b.wt, respectively suspended in groundnut oil. Group IV rats were orally administered with both dimethoate & vitamin E @ 40 & 100 mg/kg b.wt, respectively for 28 days. The clinical signs observed were decreased physical activity, dullness, depression, diarrhea, piloerection, excessive sweating, salivation, mild tremor and conjunctivitis in group III rats. Similar signs with reduced severity and absence of conjunctivitis were seen in group IV rats. There was no mortality observed throughout study in any group. Body weight of rats was significantly (P < 0.05) decrease in group III and IV rats from 21st day onwards till the end of experiment. At the end of the experiment (28th day) there was significant (p < 0.05) improvement in body weight of group IV rats as compared to group III rats. Hematology reveled significant (P <0.05) decrease in Hb, PCV, total erythrocyte count & MCV and significant (P <0.05) increase in total leukocyte count in male and female rats of group III & IV as compared to group I. Significant improvement in hematological parameters were reported in group IV rats treated with dimethoate and vitamin E as compared to group III rats treated with dimethoate alone. 1347951239.php