Meloxicam, is a newer member of oxicam
family of non-steroidal anti-inflammatory
drugs having more selectivity towards
cyclooxygenase-2 than cyclooxygenase-1.
The meloxicam study was conducted in male
buffalo calves to determine plasma
disposition and pharmacokinetics of
meloxicam (0.5 mg.kg�1) after single dose
intravenous, alone and in combination with
enrofloxacin (2.5 mg.kg�1,im). After
intravenous administration of meloxicam
when given alone, the values of distribution and elimination half�lives, volume of distribution and total body clearance were 0.68 � 0.10 h, 40.48 � 1.94 h, 0.58 � 0.03 L.kg�1 and 0.17 � 0.00 ml.min�1.kg�1, respectively. The values of distribution and elimination half�lives, volume of distribution and total body clearance were 0.71 � 0.07 h, 28.52 � 1.61 h, 0.48 � 0.02 L.kg�1 and 0.19 � 0.01ml.min�1. kg�1,respectively when meloxicam was given along with enrofloxacin. 1337248676.php