Infectious kerato-conjunctivitis (IKC) is a highly contagious disease in goats. The present study was conducted to investigate the effects of combining antibiotics and an anti-inflammatory drug to treat IKC in goats. A total of 77 clinically diseased goats were treated using seven different methods at the SAQ teaching veterinary hospital, Chittagong Veterinary and Animal Sciences University, Chittagong, Bangladesh from April 2010 to September 2012. The goats were divided randomly into seven groups with the following treatments: Group A: silver nitrate solution (1%); group B: chloramphenicol eyedrops (1%); group C: subconjunctival injection of oxytetracycline; group D: chloramphenicol eyedrops and subconjunctival injection of oxytetracycline; group E: chloramphenicol eye drops and subconjunctival injection of dexamethasone; group F: chloramphenicol eyedrops and subconjunctival injections of dexamethasone and oxytetracycline; and group G: subconjunctival injections of dexamethasone and oxytetracycline. Silver nitrate (1%) and the chloramphenicol eyedrops were applied twice daily, and all injections were administered on alternate days up to day 18. Subconjunctival injections of dexamethasone and oxytetracycline or chloramphenicol eyedrops significantly (P < 0.05) reduced IKC in goats compared with that in the other treatment groups. However, this infection was observed throughout the year in wave motion, and the incidence was highest from July to September. Females 1–12 months of age goats were subject to infection more frequently than males of all ages. These findings suggest that subconjunctival injections of dexamethasone and oxytetracycline or chloramphenicol eyedrops are useful as standard prophylactic treatment for conjunctivitis in goats with IKC. 1511874342.php