An experiment was designed to evaluate the effect of prostaglandin (PGF2α) administration and Utrovet after calving on postpartum reproductive performance in HF crossbred cows. Total 18 HF crossbred cows from potential farm of Shri Surat Panjarapole, Bhestan, Surat were selected. Group-I cows were treated with inj. Dinoprost tromethamine immediately after parturition, Group-II cows were given Tablet Utrovet (PO) on the day after parturition till 10 days, Group-III cows were treated as control. Expulsion time of placenta (hrs) was to be found significantly earlier in Group-I (2.94±0.30) as compared to Group-II (3.95±0.36) and Group-III (5.36±0.19) cows. Time taken for completion of uterine involution (days) were significantly shorter in Group-I (28.17 ±0.95) than Group-II (32.83 ± 1.28) and Group-III (37.67 ±1.30) cows. First postpartum estrus (days) was found significantly shorter in Group-I (26.50 ± 0.87) as compared to Group-II (39.00±2.84) and Group-III (48.00±2.39) cows, Service period (days) was found shorter in Group-I (60.00±4.81) as compared to Group-II (78.25±7.47) and Group-III (100.33±6.64) cows. However, number of services per conception was found non-significantly lower in Group-I (1.6±0.25) as compared to Group-II (2.0±0.41) and Group-III (2.67±0.33) and conception rate was found higher in Group-I (83.33 %) as compared to Group-II (66.67 %) and Group-III (50.00 %). It was concluded that injection of PGF2α immediately after parturition induce early expulsion of fetal membranes, accelerated the process of uterine involution and reduce the time period of first postpartum estrus in HF crossbred cows. 1427622178.php