This experiment was conducted with one hundred and fifty (150) day old (Marshal) broiler chicks which were allotted to five treatments of three replicates each in a completely randomized design (CRD). The study which lasted eight weeks was undertaken to find out the comparative advantages of Avenir (Capsicum chinense), black pepper (Pepper nigrum), Capsicum annum, and Cayenne longslim (Capsicum baccatum) and tagged T2, T3, T4 and T5 respectively as replacements for Gumboro (IBD) and Lasota vaccines in broiler chickens. They were added to the diets at inclusion level of 20g per kilogram of compounded diets. Birds fed with Capsicum annum (T4) had the higher final weight and lesser mortality (2240g, 13.33%) compared to treatment one (Control) with final weight and mortality of 1769g and 16.67%, respectively. There were no significant (P>0.05) differences in the feed intake, body weight gain and feed conversion ratio among the treatments. However, there were higher body weight gain and lower mortality rate in birds fed Capsicum annum (T4) compared to other treatments. In conclusion, using hot pepper, especially Capsicum annum, as replacement for vaccines in broiler production had no adverse effects on the growth performance of the birds. 1533984060.php