A total of 8 Landrace × Yorkshire multiparous (n = 3) sows and their piglets (n = 80, 10 piglets/sow) were used in this trial 42-day (d) to evaluate the effects of egg yolk immunoglobulin (IgY) on growth performance, diarrhea score, diarrhea incidence and serum antibody titer in pre-weaned period and durative effect on growth performance in post-weaned period in pigs. The experiment included 2 phases (phase 1: pre-weaned period for 21 d and phase 2: post-weaned period for 21 d). In phase 1, 40 piglets did not receive IgY (NC) while another 40 piglets orally received 2 ml IgY/pig (PC) on d 3. From d 10 to 21, piglets were fed with creep feed. Piglets received IgY had lower (P<0.05) diarrhea incidence and diarrhea score compared with pigs that did not receive IgY. On d 7 and 14, piglets serum antibody titer to Escherichia coli and porcine epidemic diarrhea virus in PC treatment was increased (P<0.05) compared with those in NC treatment. In conclusion, orally received IgY could increase serum antibody titer in piglets and protect piglets from diarrhea and enterotoxigenicity in pre-weaned period, however, had no effects on growth performance in pre-and post-weaned periods. 1366383597.php