The growth and physiological profiles as indices were used to evaluate the status of hybrid catfish (Clarias gariepinus (♀) and Heterobranchus bidorsalis (♂)) fed practical diet in Recirculating Aquaculture System (RAS) and Static Renewable Aquaculture System (SRAS). The study is aimed at ascertaining the suitability of growing the test fish in these systems. The trial was conducted for 12-week period with two replications. The physico-chemical parameters such as water temperature, dissolved oxygen, total alkalinity, pH, free carbon dioxide and conductivity were monitored. The result showed no significance difference (p>0.05) and were within acceptable range for hybrid catfish. The fish grown in SRAS showed insignificantly higher (p>0.05) biomass. However, all other determined growth profiles such as weight gain, daily growth rate, relative growth rate, specific growth rate, hepatosomatic index, viseromatic index, protein efficiency ratio, feed conversion ratio, gross efficiency of feed conversion, nitrogen metabolism, protein intake and survival rate were not significantly different (p>0.05). At the end of the 12-week experiment, serum, liver and kidney physiological profiles such as glucose, triglycerides, cholesterol, total protein, albumin, globulin, aspartate aminotrasferase, alanine aminotransferase, acid phosphatase, alkaline phosphatase, gamma glutamyltransferase, sodium, potassium, calcium, chloride, magnesium, inorganic phosphorous, urea, urea-nitrogen, uric acid and creatinine) were determined. There were slight differences in these profiles. This may be attributed to individual difference and the water exchange mechanism in the systems. 1377084656.php