PHARMACOKINETICS AND BIOAVAILABILITY OF KETOPROFEN AFTER SINGLE DOSE INTRAVENOUS AND INTRAMUSCULAR ADMINISTRATION IN CATTLE
Ratndeep Singh, S.K. Bhavsar*, J.H. Patel, R.D. Varia, U.D. Patel and A.M. Thaker
Date : 2014-02-26 Volume : 6

Pharmacokinetics of Ketoprofen was determined following single dose intravenous (IV) and intramuscular (IM) administration at the dose rate of 3 mg/kg body weight in cow calves. Drug concentration in plasma was determined using High Performance Liquid Chromatography. Following single dose intravenous administration, the drug was rapidly distributed (t1/2α: 0.10±0.01 h) and eliminated (t1/2β: 1.55±0.05 h; ClB: 4.82±0.16 ml/min/kg) from the body. Following intramuscular administration, the drug was rapidly absorbed (Cmax: 6.15±0.24 µg/ml; Tmax: 5 h) and eliminated (t1/2β: 3.40±0.05 h) from the body. The mean residence time (MRT) and bioavailability following intramuscular administration were 4.22±0.07 h and 77.31±2.23 %, respectively. The pharmacokinetic profile indicated that ketoprofen can be used to treat various inflammatory conditions cow calves. 1384505615.php