In most of the cases male infertility is due to low spermatozoa count, poor spermatozoa quality and DNA fragmentation. It may be the end result of one or more factors that include chronic illness, malnutrition, genetic defects, structural abnormalities, and environmental factors. Spermatozoa abnormalities may be classified on the basis of site of defect and primary, secondary abnormalities. Knobbed sperm defect, diadem defect are the two important defects of spermatozoa head. Midpiece have pseudo droplet defect and corkscrew defect; stump defect and dag defect are the specialized defects exhibited by spermatozoa tail. Normal structure of sperm chromatin and DNA damage assessment yield diagnostic and prognostic information complementary to, but distinct from, that obtained from standard sperm parameters. Therefore DNA damage assessment along with the above said may be recommended among routine tests for infertility investigations. 1320125426.php