The study was conducted to estimate the therapeutic competence of garlic (Allium sativum) on biochemical properties in lead exposed chickens. The experimental birds (350) were grouped into T0, T1, T2, T3 and T4. Group T0 served as control, group T1 was provided with lead acetate at 100mg/kg body weight, group T2 had 100mg/kg lead acetate + 1% garlic supplement, group T3 was fed with 100mg/kg lead acetate + 2% garlic supplement and group T4 had 100mg/kg lead acetate + 4% garlic supplement. The mean values (mg/dl) of Uric acid, Blood Urea Nitrogen, Creatinine, Cholesterol, Triglycerides, Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL) and Blood Glucose with lead Acetate @ 100mg/kg treatment were significantly increased (P<0.01) on 42nd Day of treatment. Elevation of serum biochemical parameters suggested the pathological involvement of liver, kidney, muscles etc. Statistical analysis of variance indicated that Lead Acetate @ 100mg/Kg + 2% Garlic supplement (T3) group resulted the significant (P<0.01) ameliorative effect on biochemical parameters in comparison to the group T2 and T4. The potency of garlic towards reverting to the values of biochemical properties close to its normal level in lead (Pb) exposed chickens that coincided with the functions as chelating agents. 1406740950.php